\documentclass[12pt]{article}

\usepackage{Sweave}
\usepackage{amsmath}
\usepackage{graphicx}
\usepackage{booktabs}
\usepackage{hyperref}
\usepackage{pdfpages}

%% \VignetteIndexEntry{Imputation of missing covariates under a multivariate linear mixed model}
%% \Vignettekeywords{multiple imputation, multivariate linear mixed model}
%% \VignettePackage{pan}

\begin{document}
\section*{Maintainer's Note}
The 1997 technical report as noted at \url{https://science.psu.edu/stat/research/technical-reports}., together with the 
subsequent publications, are all included in this vignette for convenience.

\begin{enumerate}
\item Schafer, J. L. (1997).
\emph{Imputation of Missing Covariates under a Multivariate Linear Mixed Model.}
Technical Report 97-04,
Department of Statistics, The Pennsylvania State University.

\item Schafer, J. L. (2001).
Multiple imputation with PAN.
In L. M. Collins and A. G. Sayer (Eds.),
\emph{New Methods for the Analysis of Change}
(pp.~357--377).
American Psychological Association.
\url{https://doi.org/10.1037/10409-012}

\item Schafer, J. L., and Y\"ucel, R. M. (2002).
Computational strategies for multivariate linear mixed-effects models with
missing values.
\emph{Journal of Computational and Graphical Statistics},
\textbf{11}, 437--457.
\end{enumerate}

\medskip

The marijuana data set included with the package is reproduced below. Example code can be viewed using \texttt{help(ecme, 
package = "pan")}.

\begin{table}[ht]
\centering
\caption{Change in heart rate (beats per minute above baseline) measured 15 and 90 minutes after marijuana use.}
\label{tab:heart-rate}
\begin{tabular}{crrr|rrr}
\toprule
& \multicolumn{3}{c|}{15 minutes} &
  \multicolumn{3}{c}{90 minutes} \\
\cmidrule(lr){2-4}\cmidrule(lr){5-7}
Subject & Placebo & Low & High &
Placebo & Low & High \\
\midrule
1 & 16 & 20 & 16 & 20 & -6 & -4 \\
2 & 12 & 24 & 12 & -6 & 4 & -8 \\
3 & 8 & 8 & 26 & -4 & 4 & 8 \\
4 & 20 & 8 & \textemdash & \textemdash & 20 & -4 \\
5 & 8 & 4 & -8 & \textemdash & 22 & -8 \\
6 & 10 & 20 & 28 & -20 & -4 & -4 \\
7 & 4 & 28 & 24 & 12 & 8 & 18 \\
8 & -8 & 20 & 24 & -3 & 8 & -24 \\
9 & \textemdash & 20 & 24 & 8 & 12 & \textemdash \\
\bottomrule
\end{tabular}
\end{table}

\includepdf[pages=-,width=8.5in]{tr9704.pdf}
\includepdf[pages=-,width=8.5in]{schafer01.pdf}
\includepdf[pages=-,width=8.5in]{schafer02.pdf}

\end{document}