Dose      R-1:I-y R-1:I-z R-2:I-y R-2:I-z Sample

Dose-1.044   78.9    79.8    79.0    79.1 S
Dose-1.321  108.2   113.1   119.1   122.5 S
Dose-1.670  176.9   180.1   173.6   169.8 S
Dose-1.000   79.8    76.4    78.9    78.7 T
Dose-1.265  107.2   106.5   117.7   117.3 T
Dose-1.600  168.2   171.4   179.3   162.7 T

Model                    "Parallel lines"
Design                   "Completely randomised"
Transformation           "y' = log((y+z)/2"
FUN                      "function(x) log(apply(array(x, dim = c(6, 2, 2)), c(1, 3), mean))/log(10)"
INV                      "function(x) 10^(x)"
Factor                   "1044, 104.4, 100 / 0.98653970"
Rows                     "Dilutions & Samples"
Columns                  "Replicates by pairs"
DilutionRatio            "sqrt(sqrt(1.67 * 1.6 / 1.044))"

ResultOfAssay            "Example 5: Heparin Sodium"
Project                  "CombiStats - EDQM, Council of Europe"
Description              "Three-dose parallel line assay; explicit content notation"
Comment                  "Custom transformation"
Resume                   ""
Date                     ""
Operator                 ""

Source                   "CombiStats - EDQM, Council of Europe"
URL                      "http://combistats.edqm.eu/images/stories/Examples/Heparin%20sodium.pdf"
Example                  "05"
Substance                "Heparin Sodium"
Method                   "European Pharmacopoeia (1997), 2.7.5"

StandardSample           "Ph. Eur. BRP Batch 1"
StandardAssPot           "1044 IU/ml"
StandardDilutions        "1.044 1.321 1.670"

Sample1Sample            "In-house reference"
Sample1AssPot            "1000 IU/ml"
Sample1Dilutions         "1.000 1.265 1.600"

A1@Preparations        1    0.000289614    0.000289614    1.002    0.355
A1@Regression          1    0.232114       0.232114     803.381    0.000
A1@Non-parallelism     1    3.01665E-05    3.01665E-05    0.104    0.758
A1@Non-linearity       2    0.000340714    0.000170357    0.590    0.584
A1@_Standard           1    9.14836E-05    9.14836E-05    0.317    0.594
A1@_Sample_1           1    0.000249230    0.000249230    0.863    0.389
A1@Treatments          5    0.232775       0.0465549    161.133    0.000
A1@Residual_error      6    0.00173353     0.000288922     .        .
A1@Total              11    0.234508       0.0213189       .        .
P1@Potency             .  996.153       1029.95        1064.68      .
P1@ReltoAss            .   99.6          103.0          106.5       .
P1@ReltoEst            .   96.7          100.0          103.4       .
C1@CommonSlope(factor) .    0.725012        .              .        .
C1@Correlation|r|      .    0.995503        .              .        .
