Dose       R1 R2 R3 R4  Sample

Dose-0.05   4  4  3  4  S
Dose-0.1    2  3  2  2  S
Dose-0.2    0  0  1  0  S

Dose-0.05   2  4  4  4  T
Dose-0.1    2  2  2  2  T
Dose-0.2    1  1  0  1  T

Model                    . . . . "Parallel lines"
Design                   . . . . "Completely randomised"
Transformation           . . . . "y' = y^2"
FUN                      . . . . "function(x) x^2"
INV                      . . . . "function(x) sqrt(x)"
FACTOR                   . . . . "23.75, 250, 100 / 0.932"
Factor                   . . . . "23.75, 250, NA"
Rows                     . . . . "Dilutions & Samples"
Columns                  . . . . "Replicates"
DilutionRatio            . . . . "2"

ResultOfAssay            . . . . "Example 1: Diphteria"
Project                  . . . . "CombiStats - EDQM, Council of Europe"
Description              . . . . "Three-dose parallel line assay; explicit volume units"
Comment                  . . . . "Square transformation"
Comment                  . . . . "Does not give the correct result but"
Comment                  . . . . "illustrates use of labels for doses."
Resume                   . . . . ""
Date                     . . . . ""
Operator                 . . . . ""

Source                   . . . . "CombiStats - EDQM, Council of Europe"
URL                      . . . . "http://combistats.edqm.eu/images/stories/Examples/Diphtheria%20intradermal.pdf"
Example                  . . . . "Example: 01"
Substance                . . . . "Diphteria vaccine"
Method                   . . . . "Intradermal challenge"

StandardSample           . . . . "Ph. Eur. BRP Batch 1"
StandardAssPot           . . . . "9.5 IU / dose"
StandardDilutions        . . . . "0.2 0.1 0.05"

Sample1Sample            . . . . "Batch 123456"
Sample1AssPot            . . . . "9.5 IU / dose"
Sample1Dilutions         . . . . "0.08 0.04 0.02"

A1@Preparations          1   2.66667    2.66667   0.291  0.596
A1@Regression            1 689.063    689.063    75.170  0.000
A1@Non-parallelism       1   3.06250    3.06250   0.334  0.570
A1@Non-linearity         2  32.7083    16.3542    1.784  0.196
A1@_Standard             1  10.6667    10.6667    1.164  0.295
A1@_Sample_1             1  22.0417    22.0417    2.405  0.138
A1@Treatments            5 727.500    145.500    15.873  0.000
A1@Residual_error       18 165.000      9.16667    .      .
A1@Total                23 892.500     38.8043     .      .
P1@Potency               .  16.6014    22.1352   29.2553  .
P1@ReltoAss              . 174.8      233.0     308.0     .
P1@ReltoEst              .  75.0      100.0     132.2     .
C1@Commonslope(factor)   .   9.46769     .         .      .
C1@Correlation|r|        .   0.880367    .         .      .
